Jump to content

Template:Tamoxifen dosage and incidence of breast symptoms with bicalutamide in men

From Wikipedia, the free encyclopedia
Tamoxifen doses and rates of bicalutamide-induced breast symptoms in men
Follow-up
timepoint
Tamoxifen dosage
Placebo 1 mg/day 2.5 mg/day 5 mg/day 10 mg/day 20 mg/day
0 months
6 months 98% 90% 80% 54% 22% 10%
12 months 99% 95% 84% 56% 38% 19%
Notes: Prevention of breast symptoms—specifically gynecomastia and breast pain—induced by 150 mg/day bicalutamide monotherapy with tamoxifen in 282 men with prostate cancer. Bicalutamide and tamoxifen were initiated at the same time (0 months). Estradiol levels were in the range of about 22 to 47 pg/mL in the treated group.[1] Sources: [2][1]